Leptin signaling in adipose tissue: role in lipid accumulation and weight gain.

Clinical/Translational Research Leptin Signaling in Adipose Tissue Role in Lipid Accumulation and Weight Gain Short Communication

Rationale: The link between obesity, hyperleptinemia, and development of cardiovascular disease is not completely understood. Increases in leptin have been shown to impair leptin signaling via caveolin-1–dependent mechanisms. However, the role of hyperleptinemia versus impaired leptin signaling in adipose tissue is not known. Objective: To determine the presence and significance of leptin-depen...

Leptin Signaling in Adipose Tissue Role in Lipid Accumulation and Weight Gain Short Communication

Serum Leptin concentration and some cardiovascular risk factors in response to aerobic exercise and weight loss diet in sedentary women

Introduction: Obesity is a complex disorder characterized by accumulation of excess adipose tissue. Discovery of the hormone Leptin is catalyzed the field of obesity research by demonstrating the existence of an afferent hormonal signal from adipose tissue to the central nervous system for regulation of body fat mass. The aim of this study was to assay serum Leptin concentration and some ...

Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network

Obesity is a worldwide threat to public health in modern society, which may result from leptin resistance and disorder of thermogenesis. The present study investigated whether astragaloside IV (ASI) could prevent obesity in high-fat diet (HFD)-fed and db/db mice. In HFD-fed mice, ASI prevented body weight gain, lowered serum triglyceride and total cholesterol levels, mitigated liver lipid accum...

Dietary diacylglycerol suppresses high fat and high sucrose diet-induced body fat accumulation in C57BL/6J mice.

Diacylglycerol (DG) comprises up to approximately 10% of various edible oils. In the present study, we examined the effects of dietary DG consisting mainly of 1,3-species on body weight, body fat accumulation, and mRNA levels of various genes involved in energy homeostasis in obesity-prone C57BL/6J mice. Five-month feeding with the high triacylglycerol (TG) diet (30% TG + 13% sucrose) resulted ...